Effect of plasma surface treatment of PDMS on the permeation of pharmaceutical compounds

Plasma surface treatment of PDMS membrane for permeation of pharmaceutical compounds

We recently received a nice acknowledgment in the following article from Dr. Laura Waters’ group at Huddersfield University.

An image of our UK Manufactured Henniker Plasma Treatment Equipment - HPT-100

Our model HPT-100 (pictured above), as used by Huddersfield University, is optimised for accurate, dependable and repeatable treatment of PDMS membrane and is contributing to world class research both here and in many departments across the globe. We value our close research ties very highly and are always priviledged when we have the opportunity to be involved in work of this nature.

Read an excerpt from the article below or for more information on our services scroll to the bottom of the page and click on the links.


Effect of plasma surface treatment of PDMS on the permeation of pharmaceutical compounds

Laura J Waters, Catherine V.Finch, A.K.M Mehedi H. Bhuiyan, Karl Hemming, John C. Mitchell | Department of Pharmacy, School of Applied Science, University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK | Medway Centre for Pharmaceutical Sciences, University of Greenwich, Chatham, Kent ME4 4TB, UK | Received 2 February 2017, Revised 15 May 2017, Accepted 15 May 2017, Available online 19 May 2017 | Courtesy of www.sciencedirect.com

Abstract

This paper addresses the modification of poly(dimethylsiloxane), i.e. PDMS, using plasma surface treatment and a novel application of the membrane created. A set of model compounds were analysed to determine their permeation through PDMS, both with and without plasma treatment. It was found that plasma treatment reduced permeation for the majority of compounds but had little effect on some compounds, such as caffeine, with results indicating that polarity plays an important role in permeation, as is seen in human skin. Most importantly, a direct correlation was observed between plasma-modified permeation data and literature data through calculation of membrane permeability (Kp) values suggesting plasma-modified silicone membrane (PMSM) could be considered as a suitable in vivo replacement to predict clinical skin permeation.

Graphical abstract

Plasma-modified silicone membrane has been proven to be a suitable replacement for clinical studies when determining permeation of compounds through the skin. This is the first study to propose that by modifying the surface with plasma treatment, it becomes far more ‘skin like’ thus allowing it to be used in analytical applications as a potential skin mimic system.

Keywords

  • Permeation
  • PDMS
  • Silicone
  • Plasma
  • Flux
  • Hydrophobicity

Acknowledgements

The authors wish to thank Henniker Ltd for supporting this study.


To view the remaining part of this article please use the link below

Categorised in: News & Events